1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one

ODQ is a **potent and selective inhibitor of soluble guanylyl cyclase (sGC)**, the primary receptor for nitric oxide (NO). By binding sGC, ODQ blocks NO-dependent stimulation of cGMP synthesis with high specificity (IC50 = 20 nM)[1][2][3][5][6][7]. It does not significantly inhibit other related enzymes (adenylyl cyclase, particulate guanylyl cyclase) and is commonly used in research to dissect the physiological and pathophysiological roles of the NO–cGMP signaling pathway. ODQ is cell permeable and functions as a pharmacological tool. Some evidence shows that at higher concentrations or under specific conditions, ODQ may also act as a nonselective heme protein inhibitor, affecting nitric oxide synthase and cytochrome P450 enzymes[4]. Molecular weight: 187.2 Da. Chemical formula: C9H5N3O2.

Other names

ODQ